Engineering Lipid Based Nanoparticles Using Microfluidic Arrays

Synopsis

Microfluidic chips have revolutionized the manufacturing of lipid nanoparticles and the development of novel drug delivery systems. The use of microfluidic devices offers great advantages in the optimization of lipid nanoparticles with decreased experimental times, complex flows, excellent mixing and high reproducibility. Our studies have demonstrated the continuous manufacturing of lipid nanoparticles varying from conventional to Stealth nanoparticles for passive and active targeting of cancer tumours or exosome-like delivery systems.
Our 3D printed microfluidic chips are designed for easy to scale-up production of nanoparticles with a variety of inner structures for efficient mixing of aqueous and organic flows at various ratios and flow rates. Advanced designs can be used for in situ formation of lipid nanoparticles that can be used directly for patient administration.