The Physicochemical Properties of Amorphous Isomalt as a Suitable Excipient for Freeze-drying Formulations

Time: 12:55 pm - 1:15 pm

Date: 30 April 2025

Theatre: Stream D

30-april-2025 12:55 30-april-2025 13:15 Europe/London The Physicochemical Properties of Amorphous Isomalt as a Suitable Excipient for Freeze-drying Formulations

Freeze drying, also known as lyophilization, which is the removal of water, is widely used in pharmaceutical formulation for several key reasons: 1. it can enhance the stability of active ingredients that are sensitive to heat and moisture. 2. it can extend the shelf life of pharmaceuticals and enable easier storafge and transport. 3. it… Read more »

Making Pharmaceuticals

Synopsis

Freeze drying, also known as lyophilization, which is the removal of water, is widely used in pharmaceutical formulation for several key reasons:
1. it can enhance the stability of active ingredients that are sensitive to heat and moisture.
2. it can extend the shelf life of pharmaceuticals and enable easier storafge and transport.
3. it can maintain the structural integrity of complex molecules, and
4. freeze-dried products can be effectively reconsituted by adding moisture.
This study presents differential scanning calorimetry, X-ray powder diffraction, Fourier transform infrared spectroscopy and Raman spectroscopy data for isomalt, which demonstrate its suitability as an excipient in freeze-dried formulations.
In addition the crystallization tendency of the freeze-dried isomalt samples by storing them in three different relative humidity (RH) conditions (2, 9 and 16%) at room temperature in open vials is explained.

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