29-30 April 2025
Coventry Building Society Arena
The Physicochemical Properties of Amorphous Isomalt as a Suitable Excipient for Freeze-drying Formulations
Time: 12:55 pm - 1:15 pm
Date: 30 April 2025
Theatre: Stream D
Freeze drying, also known as lyophilization, which is the removal of water, is widely used in pharmaceutical formulation for several key reasons: 1. it can enhance the stability of active ingredients that are sensitive to heat and moisture. 2. it can extend the shelf life of pharmaceuticals and enable easier storafge and transport. 3. it… Read more »
Making PharmaceuticalsSynopsis
Freeze drying, also known as lyophilization, which is the removal of water, is widely used in pharmaceutical formulation for several key reasons:
1. it can enhance the stability of active ingredients that are sensitive to heat and moisture.
2. it can extend the shelf life of pharmaceuticals and enable easier storafge and transport.
3. it can maintain the structural integrity of complex molecules, and
4. freeze-dried products can be effectively reconsituted by adding moisture.
This study presents differential scanning calorimetry, X-ray powder diffraction, Fourier transform infrared spectroscopy and Raman spectroscopy data for isomalt, which demonstrate its suitability as an excipient in freeze-dried formulations.
In addition the crystallization tendency of the freeze-dried isomalt samples by storing them in three different relative humidity (RH) conditions (2, 9 and 16%) at room temperature in open vials is explained.
Speakers
Dr Michael Black Head of Sales Pharma - BENEO GmBH
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