From Batch to Continuous – New Opportunities for Supercritical CO2 Technology in (Bio)pharmaceutical Manufacturing

Time: 12:30 pm - 12:50 pm

Date: 28 April 2020


This presentation will provide an overview on existing methods for the production of pharmaceutical nanoparticles and show case studies on the production and control of the solid state form of APIs (e.g. polymorphs, cocrystals) using batch and continuous supercritical methods. A particular focus will be provided on a novel technology that uses nano spray drying as part of a continuous process for the production, isolation and downstream processing of nanoparticles. Examples will be provided on API nanomaterials produced which feature optimal rheological properties typical of large micron-sized particles, while still maintaining high dissolution rate profiles typical of nano-sized particles.


  • Dr Luis Padrela Lecturer/Principle Investigator - SSPC, Bernal Institute, University of Limerick

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