Developing Integrated Models of Digestion, Mucus Permeation and Epithelial Absorption

Time: 4:00 pm - 4:20 pm

Date: 30 April 2019

30-april-2019 16:00 30-april-2019 16:20 Europe/London Developing Integrated Models of Digestion, Mucus Permeation and Epithelial Absorption

Oral drug delivery is often the favoured route of drug administration, but for effective delivery through the gastrointestinal tract a drug must pass in sufficient amount through three barriers to yield a biological effect, without causing significant disruption to normal function. These barriers are the digestive barrier in the lumen, the mucus barrier, and the… Read more »

Making Pharmaceuticals

Synopsis

Oral drug delivery is often the favoured route of drug administration, but for effective delivery through the gastrointestinal tract a drug must pass in sufficient amount through three barriers to yield a biological effect, without causing significant disruption to normal function. These barriers are the digestive barrier in the lumen, the mucus barrier, and the epithelial barrier.

Modelling these in vitro is fraught with difficulty, but can offer valuable insights into drug delivery. The common approach has been to model these phases in isolation with simple dissolution systems, model gut systems and cell culture systems, with the mucus barrier often being neglected.

Due to limitations of in vitro modelling, studies often progress into animal testing with limited data. Effective and predictive early stage screening systems for drug delivery would allow for data driven decisions early in the pipeline to select and optimise formulations.
At Newcastle University we have developed an integrated, in vitro model of gastrointestinal digestion and absorption for testing oral drug delivery. This is the first system of its kind capable of integrating a cell culture system with a physiologically accurate mucus layer and whole digestive secretions including bile and digestive enzymes.

In this talk we will present data showing the value of an active digestion system for simulating luminal effects, including targeted release. We will present data demonstrating the importance of understanding and modelling the mucus layer with particular reference to drug delivery in nanoparticles. And we will present data showing our current work developing a fully integrated model of the upper and lower digestive tract which includes modelling of digestion, fermentation, mucus permeation and epithelial absorption.

Speakers

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