Detecting Trace Amounts of Polymorphic Conversion With Raman Spectroscopy

Time: 4:35 pm - 4:55 pm

Date: 30 April 2019

30-april-2019 16:35 30-april-2019 16:55 Europe/London Detecting Trace Amounts of Polymorphic Conversion With Raman Spectroscopy

Detecting and understanding polymorphic conversation is critical in the development of pharmaceutical formulations. Polymorphism in drugs can impact their efficacy and the therapeutic outcome of the medicines in which they are contained. Ensuring the absence of particular polymorphs can also help to avoid patent infringement. Raman spectroscopy is a powerful analysis method to investigate polymorphic… Read more »

Making Pharmaceuticals

Synopsis

Detecting and understanding polymorphic conversation is critical in the development of pharmaceutical formulations. Polymorphism in drugs can impact their efficacy and the therapeutic outcome of the medicines in which they are contained. Ensuring the absence of particular polymorphs can also help to avoid patent infringement. Raman spectroscopy is a powerful analysis method to investigate polymorphic conversion; the specificity of this technique enables polymorphic forms of the same drug to be distinguished and the ability to perform high spatial resolution measurements enables very small amounts of conversion to be detected.
Here we apply confocal Raman imaging to two tablets; one contains a patent protected polymorph of an API, the other contains a non-protected polymorph. Raman images show a lack of the patent-protected polymorph in the second tablet, crucial in ensuring no infringement. We also show imaging of a pharmaceutical powder and the detection of two polymorphic forms of an API within this powder. These API forms comprised 0.1% and 0.3% of the analysed area.

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