Continuous Manufacturing of Pharmaceutical Nanoparticles Using Supercritical CO2-Assisted Spray Drying

Time: 9:15 am - 9:35 am

Date: 1 May 2019

1-may-2019 09:15 1-may-2019 09:35 Europe/London Continuous Manufacturing of Pharmaceutical Nanoparticles Using Supercritical CO2-Assisted Spray Drying

Over the last decade, approximately 70% of new APIs (Active Pharmaceutical Ingredients) coming through the R&D centres of large pharmaceutical companies have failed to progress due to poor solubility. Novel nanomanufacturing methods, which include supercritical fluid technologies, and nanoparticle delivery systems have been leading to breakthroughs in the enhancement of physicochemical properties of poorly water-soluble… Read more »

Making Pharmaceuticals

Synopsis

Over the last decade, approximately 70% of new APIs (Active Pharmaceutical Ingredients) coming through the R&D centres of large pharmaceutical companies have failed to progress due to poor solubility. Novel nanomanufacturing methods, which include supercritical fluid technologies, and nanoparticle delivery systems have been leading to breakthroughs in the enhancement of physicochemical properties of poorly water-soluble drugs. However, these methods have been facing challenges regarding their full implementation in the industry. One of these challenges lies with the inherent difficulties associated when scaling-up nano-processes.
Interestingly, the development of continuous and semi-continuous methodologies for drug manufacturing is providing new opportunities for a more successful adaptation of nanotechnological tools onto the industrial environment. As continuous manufacturing processes reduce the size of the manufacturing footprint, scaling-up nanomanufacturing methods becomes much more reliable or even unnecessary. By using smaller production facilities, continuous nanomanufacturing methods bear the potential to providing a wide range of benefits for poorly soluble drugs while speeding up the whole drug development process.
This presentation will provide an overview on existing methods for the production of pharmaceutical nanoparticles/nanomaterials and show a case study on the production and control of the solid state form of APIs using batch and continuous supercritical CO2 processing. A particular focus will be provided on a novel technology being developed at the University of Limerick that uses supercritical CO2-assisted spray drying as a continuous process for the production of drug nanoparticles. This presentation will also explore the mechanisms underlying the role of selected molecular additives/stabilizers in the crystallization of distinct polymorphs of APIs.

Speakers

  • Dr Luis Padrela Lecturer - Synthesis & Solid State Pharmaceutical Centre (SSPC), University of Limerick

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